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Mass Spectrometry.Point Mutation Identification.Two very different approaches to point mutation analysis are being explored by members of the Norton Group.Andrea Marcum studies the utility of MALDI-TOF Mass Spectrometry for determining single base substitutions (Hereditary hemochromatosis (HH), a common autosomal recessive disorder). Advantages of this technique include high throughput, archiving, and high sensitivity. Disadvantages include the necessity of relatively expensive instrumentation. Holly Starcher studies the use of enzyme coupled chemistry to differentiate point mutations (detection of Hereditary Hemochromatosis by DNA immobilization and colorimeteric methods). Advantages include ease of use, fast easy readout. Disadvantages include low throughput. View the Instruments we use. These tools and others are utilized to aid in understanding the nanomachine and related elements through nanotechnology. Contact The Norton NanoLaboratory with comments or inquiries. For more information, send your questions to:
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